Nanoparticles (NPs) are small particles with a surface area ranging from 1 to 100 nm in diameter that are rampantly used in different fields, e.g., medicine, engineering, and others. Because of their unique properties, such as their tiny size, magnetic properties, quantum size effects, and macroscopic quantum tunnelling effects, they are crucial for a wide range of potential applications. NPs play a significant role in the treatment of vascular disorders, the production of vaccines, and the development of drug carriers for diverse therapies due to their bioavailability, targeting ability, and efficacy. However, significant risks to the environment and health are also associated with it. NPs cause necrotic plasma membrane rupture or apoptosis, which leads to cell death. NPs interfere with cell signalling, endosomal membranes, and organelles like the nucleus or mitochondria, affecting their function. NPs cause autophagic cell death, which causes a stress response and sterile inflammation. The primary routes for the entry of NPs into the human body are inhalation, ingestion, and skin contact. NPs accumulate in the respiratory system based on their size, shape, and surface properties. NPs can cause lung inflammation and fibrosis, disrupt the endocrine system by attaching to hormone receptors, and produce reactive oxygen species (ROS) associated with DNA damage, oligospermia, and male infertility. Carcinogenic properties of NPs cause mutations, apoptosis, and inflammatory responses. Collaborative research between ecologists and epidemiologists may enlighten ways to reduce the harmful effects of NPs.

The human reference genome assembly has been available for two decades, and advancements in sequencing technology have enabled rapid whole-genome sequencing in single institutes. WGS (whole-genome sequencing) data analysis applications will enable large-scale data analysis on multi-clouds, integrate datasets with a population scale, and ensure the reproducibility of publications through modern workflow engines and scalability. In human genetics, expert-knowledge-driven approaches from medical and biological professionals and data-driven approaches from computer science applied to epidemiology, such as AI (artificial intelligence), are required for domain-specific downstream data interpretations. For reliable diagnostic, prognostic, and therapeutic tools, as well as generalized outcomes, genomic studies should involve a wide range of majority and minority populations. The field of genomics in medicine is entering a new era, and to increase the application of gene therapy in the treatment of emerging infections and disorders, there needs to be a united worldwide effort.

Systematic reviews that are out-of-date delay policymaking, create controversy, and can erode trust in research. To avoid this issue, it is preferable to keep summaries of the study evidence. Living evidence is a synthesis approach that provides up-to-date rigorous research evidence summaries to decision-makers. This strategy is particularly useful in rapidly expanding research domains, uncertain existing evidence, and new research that may impact policy or practice, ensuring that physicians have access to the most recent evidence. Addressing global challenges - ranging from public health crises to climate change or political instability - requires evidence-based judgements. An obsolete, biased, or selective information poses risks of poor decisions and resource misallocation. The relatively nascent practice of living evidence proves invaluable in maintaining continuous interest and team engagement. The concept of living evidence has been particularly relevant during the COVID-19 pandemic due to the rapidly evolving nature of the virus, the urgent need for timely information, and the continuous emergence of new research findings. Although the COVID-19 pandemic accelerated the adoption of evidence systems, researchers and funders of research should rigorously test the living-evidence model across diverse domains to further advance and optimize its methodology.

Indian subcontinent has high mental heath burden and low resources to cope the mental health challenges. Assessment of impact of COVID-19 pandemic on the mental health would help to prioritize the resource allocations. We aimed to assess the impact of COVID-19 on the mental health of people in the Indian subcontinent. Following the PRISMA 2020 guideline, a scoping review was performed by systematically searching the PubMed, Scopus, and Embase databases to identify original studies that assessed mental health conditions during the COVID-19 pandemic in the Indian subcontinent. In this review, a total of 34 studies conducted between 2020 and 2022 were analyzed. The prevalence of anxiety disorders was found to range widely, from 2.5% in North Indian urban slum to 53% in Bangladesh and 21.7% in Pakistan. Similarly, the prevalence of depression varied widely, with rates ranging from 3.5% in North India to 29.8% in Pakistan. The prevalence of stress-related problems ranged from 18.3% in Pakistan to 59.7% in Bangladesh. Factors such as female gender, married status, healthcare workers, and mental illness were identified as important predictors of anxiety and depressive disorders. The impact of COVID-19 pandemic on mental health in Indian subcontinent varies widely based on study population and methods. Therefore, a cautious interpretation is needed while generalizing the study results.

Academic and Industry Partnership Research Grants have a huge potential to improve healthcare in the UK and elsewhere. This potent partnership between academia and business can hasten medical innovation, strengthen patient-centered research, and close the gap between theoretical understanding and real-world implementations. We can make sure that the quest of scientific knowledge continues to be at the forefront of healthcare developments by welcoming this partnership while respecting ethical norms and transparency. The UK's dedication to developing long-term alliances based on mutual respect and open dialogue will help create a climate in which ground-breaking research may flourish and be transformed into affordable healthcare solutions.

The language of science is communicated through various modes, such as lectures, informal discussions, conferences, and peer-reviewed publications. Artificial Intelligence (AI) based writing tools, like ChatGPT, have recently become increasingly popular due to natural language processing technology advancements. ChatGPT is an AI language model that can generate text close to human writing, making it suitable for tasks such as summarizing literature, composing essays, and producing statistical studies. This technology has the potential to transform scientific communication, but concerns have been raised about its impact on the integrity of research and the role of human researchers. While this technology has advantages such as accelerating the innovation process and enhancing diversity in scientific viewpoints, it is important for the scientific community to debate and envision the consequences of its use. Publishers are working to develop guidelines for its application, which may be capable of future activities such as experiment design and peer review. As we enter the early stages of the AI revolution, it is imperative that the scientific community engages in discourse and contemplate the potential outcomes of this potentially transformative technology. With this in mind, we have outlined relevant topics as a starting point for discussion.

Complex Innovative Trial Design (CID) offers several potential benefits for clinical research, including the use of novel statistical techniques such as adaptive designs and Bayesian methods that require computer simulation to determine operating characteristics. By leveraging these techniques, CID has the potential to increase the probability of success for clinical trials while simultaneously reducing the time and cost required for drug development.

Cigarettes and alternative tobacco products cause various oral health issues ranging from minor tooth decay/gum-diseases to oral cancer. According to the Centre for Disease Control (CDC), over 40% of adult cigarette smokers have untreated tooth decay which later leads to severe oral health problems. The present study intended to assess the impact of dentists' perceived risk of smoking tobacco products on their attitude and practice toward tobacco cessation advice. It was a cross-sectional study to collect data on the perception of dentists who are smokers, regarding smoking-related health risks. Dentists' attitude was measured using a questionnaire with a 5-point rating scale and a practice list of items with a 3-point rating scale. Descriptive/inferential techniques were applied, and a significance level was fixed at 5%. Among the 31 tobacco users, 80.6% of dentists perceived severe risk with cigarette use as compared to alternative tobacco products (71%). Positive attitude and good practice were observed among those who perceived severe risk; however, no statistical significance was observed (p-value >0.05). Young dentists, males, Arab nationals, highly educated and specialists had a positive attitude toward smoking cessation activities. Among the smokers, dentists recognize their role and responsibility very seriously in building a smoke-free community, but their risk perception and good attitude did not positively reflect on their clinical practice in smoking cessation programs. Though the dentists had a better perception and attitude towards smoking cessation, their clinical practice in offering advising sessions is inversely related to their perception/attitude.

Knife crime has become a common phrase used by the media, but it is not always clear what it refers to or what they mean when they use the term. Knife crime can cover many offences, making it challenging to define and estimate its prevalence. This review aimed to evaluate potential knife crimes in the UK from 2011 to 2021 and analyse the causes and risk factors associated with the crimes. Six UK online news portals were purposefully chosen to be included in the study, and knife crime news was searched retrospectively. The term "knife crime" was used to search. The news portals were the: Metro, the Sun, the Guardian, Daily Mail, Daily Mirror and the Evening Standard. In the assigned news portals, 692 reports were found between January 2011 and December 2021. The study revealed that the 11-20 years of age group individuals are more vulnerable as victims, and males are more reported as victims when compared to females. About 61.8% of knife crimes are reported from South England. Knife crime risk is higher in early adulthood and among males. Street violence, fights/gang attacks, family issues and robbery are the leading causes of knife crime and have all been identified as risk factors that must be addressed with caution.

To date, there is the continuous emergence of novel infectious diseases endangering individuals' health and well-being worldwide. Over the past few decades, around forty contagious diseases, such as Severe Acute Respiratory Syndrome coronavirus-1 (SARS), Middle East Respiratory Syndrome coronavirus (MERS), Ebola, Zika, and newly, COVID-19 and Monkeypox outbreaks, have been reported globally. Zoonotic transmission is the major cause of these emerging infections in humans. These, whether caused by previously unknown pathogens or by those already well-known to science, heighten global concerns about the spread of communicable diseases and the resulting increase in death and disability.